Research & Evidence

Integrated Spine, Pain & Wellness and Dr. Ashu Goyle

A Scientific Foundation for Healing

 

At Integrated Spine, Pain & Wellness, we believe in care that’s rooted in evidence—not guesswork. Our approach blends cutting-edge research with thoughtful clinical application, so every therapy we offer is informed by what science is learning about healing, pain pathways, and long-term recovery.

From biologic therapies like PRP and bone marrow-derived treatments to peptide modulation and nervous system support, the treatments we select are grounded in ongoing research that explores how the body heals itself, how pain signals can be modulated, and how function can be restored.

Research in regenerative medicine continues to evolve rapidly. For example, studies suggest that platelet-rich plasma (PRP) may support pain reduction and improve function for certain joint and soft-tissue conditions, often outperforming traditional injections like corticosteroids in long-term follow-up. 

On this page, you’ll find peer-reviewed studies, clinical guidelines, and emerging evidence that support and contextualize the therapies we offer. Our goal is to help you understand both the promise and the limits of current science, so you can make informed decisions about your care.

 

The Time of Blood Collection Does Not Alter the Composition of Leucocyte-Poor Platelet-Rich Plasma: A Quantitative Analysis of Platelets and Key Regenerative Proteins 

 

New Study: Exosome Therapy from Umbilical Cord Stem Cells Shows Early Promise for Osteoarthritis

 

Non-surgical treatment of anterior cruciate ligament tears with percutaneous bone marrow concentrate and platelet products versus exercise therapy: a randomized-controlled, crossover trial with 2-year follow-up

Springer Nature, 2025 

 

Establishing metrics of clinically meaningful change for treating knee osteoarthritis with a combination of autologous orthobiologics
Nature, 2025

 

Intradiscal Injections of Bone Marrow Concentrate or Leukocyte-Rich Platelet-Rich Plasma for the Treatment of Cervical Discogenic Pain: A Case Series
Cureus, 2025

 

Percutaneous autologous bone marrow concentrate for knee osteoarthritis: patient-reported outcomes and progenitor cell content
International Orthopaedics, 2022

 

Evidence-Based Clinical Practice Guidelines on Regenerative Medicine Treatment for Chronic Pain: A Consensus Report from a Multispecialty Working Group
Dovepress, 2024

 

The rate of venous thromboembolism after knee bone marrow concentrate procedures: should we anticoagulate?
International Orthopaedics, 2022

 

Percutaneous bone marrow concentrate and platelet products versus exercise therapy for the treatment of rotator cuff tears: a randomized controlled, crossover trial with 2-year follow-up
IBMC Musculoskelet Disord, 2024